Measurements at a standardised time¶ during constant-load exercise after treatment with placebo and salmeterol
| Placebo | Salmeterol | |
| Dyspnoea Borg | 3.6±0.4 | 2.7±0.3# |
| Leg discomfort Borg | 4.0±0.3 | 3.7±0.4 |
| V'O2 mL·kg−1·min−1 | 14.1±0.9 | 14.7±1.1 |
| V'CO2 L·min−1 | 1.01±0.10 | 1.09±0.12* |
| V'E L·min−1 | 31.9±2.4 | 34.0±2.7* |
| V'E/V'CO2 | 33.5±1.3 | 33.0±1.2 |
| fR breaths·min−1 | 29.0±1.2 | 27.7±1.2 |
| VT L | 1.12±0.09 | 1.23±0.08* |
| IC L | 1.48±0.11 | 1.65±0.09* |
| Change in IC from rest L | −0.34±0.04 | −0.50±0.05* |
| IRV L | 0.36±0.05 | 0.43±0.03 |
| EILV %TLC | 95±1 | 94±1 |
| % pred TLC | 118±4 | 117±4 |
| VT/tE L·s−1 | 0.87±0.07 | 0.93±0.08* |
| VT/tI L·s−1 | 1.42±0.09 | 1.50±0.10* |
| tE s | 1.36±0.07 | 1.42±0.07 |
| tI/ttot | 0.37±0.01 | 0.37±0.01 |
| fc beats·min−1 | 109±3 | 111±4 |
| Sa,O2 % | 93.7±0.5 | 94.1±0.3 |
Data are presented as mean±sem
V'O2: oxygen uptake
V'CO2: carbon dioxide output
V'E: ventilation
fR: respiratory frequency
VT: tidal volume
IC: inspiratory capacity
IRV: inspiratory reserve volume
EILV: end-inspiratory lung volume
TLC: total lung capacity
tE: expiratory time
VT/tE: mean expiratory tidal flow rate
tI: inspiratory time
VT/tI: mean inspiratory tidal flow rate
ttot: duration of total breathing cycle
tI/ttot: inspiratory duty cycle
fc: cardiac frequency
Sa,O2: arterial oxygen saturation
% pred: per cent predicted
¶: 3.4±0.5 min
*: p<0.05
#: p=0.07 versus placebo