Lung volumes, gas transfer and haemoglobin before and after bone marrow transplantation (BMT) in 39 consecutive patients with malignant blood disorders treated with BMT and busulphan/cyclophosphamide conditioning (patients with obliterative bronchiolitis excluded)
| Pre-BMT | 3 months | 12 months | 5 yrs | |
| FVC % pred | 108±15 | 99±17*** | 102±16 | 109±16 |
| FEV1 % pred | 103±12 | 96±13* | 99±13 | 102±13 |
| FEV1/FVC % | 80±7 | 84±8* | 82±8 | 78±7 |
| TL,CO % pred | 88±17 | 63±16*** | 70±14*** | 85±15 |
| TL,CO-Hb % pred | 94±15 | 73±19*** | 76±15*** | 88±15 |
| Hb g·100 mL−1 | 13.0±2.2 | 10.4±1.4*** | 12.5±1.4 | 13.8±0.8 |
Data are presented as mean±sd
Statistical comparisons: values at the time of maximum impairment (i.e. 3 months) and values at 12 months and 5 yrs after BMT are compared with values pre-BMT
FVC: forced vital capacity
% pred: per cent predicted
FEV1: forced expiratory volume in one second
TL,CO: transfer factor of the lung for carbon monoxide
TL,CO-Hb: transfer factor of the lung for carbon monoxide corrected for haemoglobin level
Hb: haemoglobin
*: p<0.05
***: p<0.001, Bonferroni's correction for multiple comparisons