Effect of tiotropium (pooled AM and PM) versus placebo on pre- and post-sleep forced expiratory volume in one second (FEV1) and forced vital capacity (FVC)
| Tiotropium | Placebo | Difference | p-value | 95% CI | |
| Pre-sleep FEV1 L | 0.91 (0.03) | 0.72 (0.05) | 0.19 | 0.002 | 0.07–0.31 |
| Patients n | 40 | 15 | |||
| Post-sleep FEV1 L | 0.81 (0.02) | 0.64 (0.03) | 0.17 | 0.0001 | 0.09–0.26 |
| Patients n | 38 | 16 | |||
| Pre-sleep FVC L | 2.18 (0.07) | 1.87 (0.12) | 0.31 | 0.027 | 0.04–0.58 |
| Patients n | 40 | 15 | |||
| Post-sleep FVC L | 1.94 (0.06) | 1.58 (0.09) | 0.36 | 0.001 | 0.15–0.57 |
| Patients n | 38 | 16 |
Data are presented as mean (se) from the patient population with total sleep time of at least 2 h (n=56)
Means are adjusted for end-point baseline and baseline arterial oxygen tension
Overall mean baseline FEV1: pre-sleep: 0.84 L
post-sleep: 0.76 L
Overall mean baseline FVC: pre-sleep: 2.03 L; post-sleep: 1.79 L