Table 2

Oxygen saturation (%) during rapid eye movement (REM) sleep and differences between treatment groups at end of study

Comparison	Tiotropium-AM	Tiotropium-PM	Tiotropium pooled	Placebo	Difference in % points	p-value	95% CI
Subjects n	19	17	36	11
Tiotropium-AM versus placebo	89.97 (0.59)			87.56 (0.76)	2.41	0.016	0.48–4.33
Tiotropium-PM versus placebo		89.98 (0.62)		87.56	2.42	0.020	0.41–4.43
Tiotropium pooled versus placebo			89.98 (0.41)	87.56	2.41	0.008	0.68–4.15

Data are presented as mean (se) unless otherwise stated and are from the patient population with total sleep time of at least 2 h
Some patients did not have any REM sleep at baseline or end of study
Means are adjusted for baseline arterial oxygen saturation (S_a,O₂) and arterial oxygen tension. Overall mean baseline S_a,O₂ during REM sleep=88.74%