Target fall in FEV1 % | Pretreatment with placebo | PD (µmol) | Pretreatment with regular salbutamol | PD (µmol) | ||||
Before MCh | After MCh | % change | Before MCh | After MCh | % change | |||
0 | 2.19 (1.75–2.62) | NA | 0 | 0 | 1.96 (1.56–2.36) | NA | 0 | 0 |
15 | 2.21 (1.80–2.63) | 1.81 (1.36–2.02) | 18.0 (16.6–20.6) | 0.11 (0.09–0.14) | 2.07 (1.66–2.49) | 1.81 (1.36–2.03) | 18.2 (16.0–19.9) | 0.17 (0.09–0.32) |
30 | 2.27 (1.87–2.67) | 1.49 (1.22–1.75) | 34.6 (32.2–36.5) | 0.71 (0.57–0.87) | 2.09 (1.70–2.49) | 1.48 (1.11–1.67) | 33.6 (32.1–36.0) | 0.72 (0.34–1.53) |
Data are presented as mean (95% confidence intervals). The provocative dose (PD) of methacholine is given as the geometric mean (µmol). The target fall in the FEV1 was achieved on separate days in random order
MCh: methacholine
NA: not applicable