Mediators and neurotransmitters involved in indirect bronchial responsiveness
| Mediator Release | Neuronal Stimulation | References | |
| Adenosine | +(Hi, LT, PG) | +(ACh, TK?) | 27, 39–49 |
| Tachykinins | +(Hi, LT, PG) | +(ACh) | 50–56 |
| Bradykinin | +(Hi, PG, NO) | +(ACh, TK?) | 57–63 |
| Propranolol | ±(Hi) | +(ACh) | 64–68 |
| Metabisulphite/SO2 | +(Hi, LT, PG) | +(ACh, TK?) | 47, 69–75 |
| Exercise | +(Hi, LT, PG) | +(ACh,TK) | 19, 21, 22, 24, 27–30, 34, 76, 77–82 |
| Nonisotonic aerosols | +(Hi, LT, PG) | +(ACh, TK?) | 17, 83–88 |
| EVH of dry air | +(Hi, LT) | +(ACh, TK?) | 26, 30, 89–94 |
| PAF | +(LT?) | ± | 95 |
| Aspirin | +(PG, LT) | ? | 96 |
| Allergen | +(Hi, PG, LT, TK?) | ± | 97–103 |
Hi: histamine
LT: leukotriene C4, D4, E4
PG: prostaglandins
ACh: acetylcholine
TK: tachykinins
NO: nitric oxide
EVH: eucapnic voluntary hyperpnoea
PAF: platelet activating factor
?: not known for human airways
This table was modified from 7