Table 4

Commonly used antibiotics and efficacy in the treatment of actinomycosis

AntibioticMIC range mg·mL−1[Ref.]
Efficacious#
 Penicillin≤0.25–0.5 63
 Tetracycline (doxycycline)0.5–0.8 63
 Erythromycin≤0.25–1 26
 Clindamycin≤0.25–0.5 26
Probable efficacy
 Imipenem0.12564, 65
 Ceftriaxone<0.06–266, 67
Ineffective+
 Flouroquinolones (ciprofloxacin)0.5–128 63
 Metronidazole2–>128 63
 Aminoglycosides (amikacin)≤0.25–1 26

  • #: considerable successful clinical experience

  • : anecdotal successful reports

  • +: ineffective in vitro