History of treatments for pulmonary arterial hypertension
| Year | Treatment |
| 1950–1980 | Empirical/various vasodilators for acute vasoreactivity testing (tolazoline, acetylcholine, diazoxide, hydralazine, phentolamine, isoproterenol, nitrates, verapamil, nifedipine and diltiazem) |
| 1970–1980 | Uncontrolled trials on long-term vasodilator treatments |
| 1980– | Oral anticoagulants |
| High-dose calciumchannel antagonists (in acute vasoreactivity tests responders) | |
| Lung, heart/lung transplantation | |
| 1990– | Intravenous epoprostenol prostacyclin |
| Balloon atrial septostomy | |
| 2000– | New compounds |