Date | Landmark |
1944 | SM and PAS |
1948 | Randomised trial, SM versus PAS versus SM/PAS |
1952 | Triple therapy, isoniazid/SM/PAS, 24 months |
1960s | EMB replaces PAS, 18 months |
1970s | RIF added to INH/EMB/SM, 9 months |
1980s | PZA added to INH/RIF, 6 months |
SM: streptomycin
PAS: para-amino salt of salicylic acid
RIF: rifampicin
EMB: ethambutol
INH: isonicotinic acid hydrazide
PZA: pyrazinamide