First author [ref. no] | Study | Aetiology of ARF | Patients n | PH | Pa,CO2 mmHg | Duration of NPPV application | LOS ICU days | Intubation n | Survival rate % | ||
h·day−1 | h | days | |||||||||
Meduri 30 | O | Hypercapnic ARF | 18 | 7.29 | 72 | 25 | 1 | NA | 5 | 94 | |
Brochard 31 | HM | COPD | 13 | 7.29 | 65 | 7.6 | 3 | 3d | 1 | 85 | |
Kramer 7 | PR | ARF | 16 | 7.27 | 74.3 | 14.4 | 3.8±1.4 | NA | 5 | 93.7 | |
Barbe 12 | PRC | COPD | 34 | 7.33 | 56 | 6 | 3 | 0 | 0 | 100 | |
Fernandez 32 | O | COPD | 12 | 7.19 | 92 | 8±4 | NA | 7.6±1.7 | 3 | 93 | |
Lin 10 | PR | APO | 50 | 7.40 | 32.9 | 6 | NA | 4±3 | 8 | 92 | |
Mehta 13 | PRC | APO | 14 | 7.25 | 56 | 7.1±4.7 | NA | 2.3±3.7 | 1 | 93 | |
Wysocki 33 | PRC | COPD | 21 | 7.39 | 44 | 7.6±11.8 | 1.5±1 | 17±19 | 13 | 67 | |
Poponick 34 | O | ARF | 58 | 7.26 | 75.3 | 0.5 | NA | 4.2 | 13 | 96.5 | |
Celikel 15 | PRC | Hypercapnic ARF | 15 | 7.28 | 67 | 26.7±16.1 | NA | 11.7 | 1 | 100 | |
Wood 16 | PRC | ARF | 16 | 7.35 | 56.5 | NA | 5.8±5.5 | 7 | 75 | ||
Plant 19 | PRC | COPD | 118 | 7.32 | 61.7 | 8 | 3 | NA | 18 | 89.8 | |
Antonelli 35 | PRC | ARF | 32 | 7.45 | 38 | NA | 9±7 | 10 | 71.8 | ||
Thys | PRPC | COPD and APO | 10 | 7.28 | 57 | 1.59±0.48 | 1 | 2.7±3.5 | 0 | 80 | |
Thys placebo | PRPC | COPD and APO | 10 | 7.24 | 61 | 0.48±0.28 | 1 | 5.4±5.6 | 3 | 90 |
O: open study
HM: historical matched
PR: prospective randomised
PRC: prospective randomised controlled
PRPC: prospective randomised placebo-controlled
ARF: acute respiratory failure
COPD: chronic obstructive pulmonary disease
APO: acute pulmonary oedema
NA: not available
ICU: intensive care unit
Previous studies: patients with active NPPV
Present study: patients with active and placebo NPPV
1 mmHg=0.133 kpA