[Ref. no.] | No. patients/controls | Type of study | Methods | Results |
69 | 61 | Case-control | Serology (mIF) | Elevated polyvalent ab levels to C. pneumoniae associated with wheezing, in four cases new asthma diagnosed. |
304 | ||||
70 | 332 | Case-control | Serology (mIF) | Long-standing nonatopic asthma strongly associated with elevated IgG ab levels to C. pneumoniae |
98 | ||||
71 | 169 | Case-control | Serology (mIF) | Elevated IgG and/or IgA ab levels to C. pneumoniae associated with severe chronic asthma. |
1518 | ||||
72 | 619 | Uncontrolled cohort | Serology (mIF) | High-dose inhaled steroids associated with elevated IgG and IgA ab levels to C. pneumoniae. Inverse association between IgG abs and lung function. |
9 | 108 | Partly-controlled cohort | Secretory IgA (EIA) | Elevated specific secretory IgA levels and PCR positivity in subsequent samples associated with multiple exacerbations. |
PCR |
mIF: microimmunofluorescence test
EIA: enzyme immunoassay
PCR: polymerase chain reaction
Ig: immunoglobulin
ab: antibody