Adverse event profile
| Tiotropium | Placebo | |
| Subjects n | 550 | 371 |
| Adverse events n (%) | 495 (90.0) | 338 (91.1) |
| Adverse events considered drug related | 104 (18.9) | 34 (9.2)* |
| Dry mouth n (%) | 88 (16.0) | 10 (2.7)* |
| Deaths | 7 (1.3) | 7 (1.9) |
| Serious adverse events n (%) | 99 (18.0) | 78 (21.0) |
| Adverse events leading to discontinuation n (%) | 53 (9.6) | 51 (13.7) |
*: p<0.05