Table 2—

T-helper (Th)-1/Th-2 imbalance at birth and development of atopy

cytokinestimulusoutcomefollow-up yrs1st author [ref no.]
IFN-γ ↓allergenatopic eczema, skin test reactivity1Warner 36
IFN-γ ↓mitogenskin test reactivity1Tang 38
IFN-γ ↓mitogen (at 9 months)skin test reactivity6Martinez 39
IL-2 ↓
IL-4/IL-5 ↑allergen-TCCatopy3Piccini 40
IFN-γ=
IFN-γallergenallergic disease6Kondo 37
Persistance of foetal Th2↑ Th1 ↓allergenatopy2Prescott 35, 41

  • IFN: interferon

  • IL: interleukin

  • TCC: T-cell clones