Table 2—

Summary of seasonal and post contact prophylaxis with neuraminidase inhibitors

ReferenceProphylaxis treatmentDurationSubjectsAge yrsProtective efficacy and comments
97 Zanamivir 10 mg inhaled b.i.d4-week seasonal over outbreak110718–6967% against laboratory-confirmed influenza infection, 84% against clinical illness.
98 Oseltamivir 75 mg once daily or b.i.d6/52 seasonal study155918–6574% against laboratory-confirmed influenza infection, no difference between once daily and b.i.d. no emergence of resistance.
99 Oseltamivir 75 mg once daily6/52 seasonal study in nursing home548Mean of 8292% in prevaccinated group 8 reduction in complications.
100 Oseltamivir 75 mg once dailyHousehold contacts 5/7377 householdsHealthy adults82%