DTPA clearance variable | Time to decline in FVC | |||
SSc-ILD | IPF | |||
HR (95% CI) | p-value | HR (95% CI) | p-value | |
Increasing rapid total clearance# min | 1.02 (1.01–1.03) | 0.001 | 0.99 (0.97–1.00) | 0.11 |
Patients with an abnormal clearance# min | 2.10 (1.25–3.53) | 0.005 | 0.59 (0.28–1.26) | 0.18 |
Increasing rapid fast clearance¶ min | 1.15 (1.04–1.28) | <0.01 | 0.98 (0.92–1.04) | 0.47 |
Increasing %FC¶ | 1.02 (1.00–1.04) | 0.02 | 0.99 (0.97–1.01) | 0.39 |
Increasing delayed slow clearance¶ min | 0.99 (0.98–1.01) | 0.36 | 1.01 (1.00–1.02) | <0.01 |
FVC: forced vital capacity; DTPA: diethylene triamine pentacetate; ILD: interstitial lung disease; SSc: systemic sclerosis; IPF: idiopathic pulmonary fibrosis; HR: hazard ratio; %FC: % DTPA cleared by the fast component. #: 168 SSc-ILD patients and 97 IPF patients; ¶: 126 SSc-ILD patients and 81 IPF patients.