Author | [Ref.] | Subjects | Findings | Comments |
Backer Denmark, 1992 | 93 | 508 subjects aged 7–16 yrs | No relationship between active smoking and IgE in univariate analysis | Active smoking increased IgE after adjustment for age, SPT positivity, allergic symptoms and family history of allergic disease |
Jensen Denmark, 1992 | 65 | 297 smoking volunteers and 137 random controls at follow-up of: 1 yr; mean age: 44.2 yrs | Higher IgE among smokers than among nonsmokers in both sexes. Weighted pack-yr consumption associated with increased IgE | Quitters had increased IgE levels during the first 26 weeks of abstinence. Return to baseline after one yr |
Sherrill USA, 1994 | 57 | General population: 2,350 subjects seen at least 1 time during follow-up, spanning up a period of 20 yrs, aged >6 yrs at the first survey (1973) | Higher IgE among smokers than nonsmokers in both sexes. Positive association between pack-yrs and level of IgE, stronger in male subjects | No significant difference of IgE between sexes in nonatopic subjects |
Omenaas Norway, 1994 | 17 | 1,512 subjects in four groups - asthmatics - nonasthmatics exposed at work -nonsmokers free of respiratory symptoms - general population aged 18–73 yrs | Higher IgE among smokers than nonsmokers | Subjects examined during the summer tended to have higher IgE level than those examined in winter. Subjects with occpuational dust or gas exposure had a higher total IgE level than unexposed. Levels of total IgE did not differ significantly by educational level |
Jarvis England, 1995 | 62 | General population: two samples drawn from ECRHS aged 20–44 yrs: 367 subjects, free of respiratory symptoms, 135 subjects symptomatic but without asthma before age 14 yrs | Higher IgE among smokers than nonsmokers. Difference greater in females but not significant. Weaker but positive associations between pack-yrs and level of IgE. Higher IgE among smokers than nonsmokers | In young adults, smoking explains little of the variation in total IgE (<1%) |
Lai China, 1995 | 94 | General population: 195 subjects among 2,032 aged ≥70 yrs | Higher IgE among smokers than nonsmokers | |
Wüthrich Switzerland, 1996 | 95 | General population: 8,344 subjects aged 18–60 yrs | Higher IgE among smokers than nonsmokers | |
Sapigni Italy, 1998 | 21 | General population: 1,905 subjects aged 8–73 yrs | Higher IgE among smokers than ex/nonsmokers. A dose-response relationship between IgE and cigarette consumption in males | No difference between non and exsmokers |
SPT: skin prick test; ECRHS: European Community Respiratory Health Survey.