TABLE 2

Statistical analysis of treatment effects in study 1

	Treatment difference: peak FEV₁ L		Treatment difference: FEV₁ average effect 0–8 h L
	Difference (95% CI)	p-value	Difference (95% CI)	p-value
*Salbutamol versus* placebo**	0.187 (0.142–0.232)	<0.001	0.123 (0.087–0.159)	<0.001
*Ipratropium versus* placebo**	0.199 (0.153–0.244)	<0.001	0.165 (0.128–0.201)	<0.001
*RPL554 versus* placebo**	0.223 (0.178–0.269)	<0.001	0.165 (0.133–0.206)	<0.001
*Salbutamol+RPL554 versus* placebo**	0.292 (0.250–0.340)	<0.001	0.235 (0.199–0.271)	<0.001
*Ipratropium+RPL554 versus* placebo**	0.292 (0.247–0.337)	<0.001	0.229 (0.192–0.265)	<0.001
*RPL554 versus* salbutamol**	0.039 (−0.009–0.081)	0.120	0.046 (0.010–0.082)	0.0136
*RPL554 versus* ipratropium**	0.024 (−0.021–0.070)	0.294	0.004 (−0.032–0.041)	0.8148
*Salbutamol versus* ipratropium**	−0.012 (−0.057–0.034)	0.614	−0.042 (−0.078–0.005)	0.0245
*Salbutamol+RPL554 versus* salbutamol**	0.108 (0.063–0.153)	<0.001	0.112 (0.076–0.148)	<0.001
*Ipratropium+RPL554 versus* ipratropium**	0.094 (0.049–0.139)	<0.001	0.064 (0.028–0.100)	0.0006

FEV₁: forced expiratory volume in 1 s.