TABLE 3

Effectiveness results (intention to treat analysis set) of Urban Training intervention at 12 months in chronic obstructive pulmonary disease (COPD) patients

Usual care#Urban Training#Adjusted difference (95% CI) at 12 months
Baseline12 monthsBaseline12 months
Subjects n148132
Primary outcome
 Steps per day7783±38477825±38508069±45548002±4635−24 (−741–693)
Secondary outcomes
 Any severe COPD exacerbation in previous 12 months %1417+817+0.3 (−0.4–1.0)
 6MWD m501±83493±90+499±95488±106+−1.5 (−11–8)
 BMI kg·m−228.3±4.628.3±4.528.4±5.028.5±5.20.0 (−0.3–0.4)
 FFMI kg·m−219.6±3.219.5±3.019.6±3.019.6±3.10.1 (−0.4–0.5)
 Health-related quality of life (CAT)12±811±712±711±7+0.1 (−1.1–1.2)
 Health-related quality of life (CCQ total)1±11±11±11±1+−0.1 (−0.3–0.1)
 Anxiety (HAD-A)5±44±4+5±45±4+0.2 (−0.4–0.9)
 Depression (HAD-D)3±33±34±33±3+−0.5 (−1.0–0.1)
Exploratory outcomes
 Cognitive status (phototest)37±536±536±537±50.6 (−0.2–1.5)
 Physical activity experience (C-PPAC total)79±1277±1278±1280±142.6 (−0.8–6.0)
 Physical activity experience of amount (C-PPAC amount)75±1573±1574±1574±181.5 (−2.5–5.5)
 Physical activity experience of difficulty (C-PPAC difficulty)83±1381±1482±1585±15+3.8 (−0.2–7.9)

Data are presented as mean±sd, unless otherwise stated. 6MWD: 6-min walking distance; BMI: body mass index; FFMI: fat-free mass index; CAT: COPD Assessment Test; CCQ: Clinical COPD Questionnaire; HAD: Hospital Anxiety and Depression Scale; C-PPAC: Clinical visit – PROactive Physical Activity in COPD (higher numbers indicate a better score). #: some variables have missing values, as follows. At baseline in the usual-care group: severe COPD exacerbations (n=1), FFMI (n=18), HAD-A (n=2), HAD-D (n=2), C-PPAC total (n=25), C-PPAC amount (n=24) and C-PPAC difficulty (n=25); at 12 months in the usual-care group: severe COPD exacerbations (n=5), 6MWD (n=8), BMI (n=3), FFMI (n=3), CAT (n=2), CCQ total (n=2), HAD-A (n=2), HAD-D (n=2), cognitive status (n=2) and C-PPAC total, amount and difficulty scores (n=64); at baseline in Urban Training group: severe COPD exacerbations (n=2), FFMI (n=12), CCQ total (n=2), HAD-D (n=1) and C-PPAC total, C-PPAC amount and C-PPAC difficulty (n=35); at 12 months in Urban Training group: severe COPD exacerbations (n=5), 6MWD (n=3), BMI (n=2), FFMI (n=2), CAT (n=2), CCQ total (n=3), HAD-A (n=2), HAD-D (n=4), cognitive status (n=2) and C-PPAC total, amount and difficulty scores (n=70); : multivariable models (linear regression for all outcomes except exacerbations where logistic regression was used) adjusted by group and the corresponding outcome values at baseline; + p-value of final versus baseline <0.05.