pKi | t1/2 h | |||||
M1 | M2 | M3 | M1 | M2 | M3 | |
Ipratropium | 9.40 | 9.53 | 9.58 | 0.1 | 0.03 | 0.22 |
Aclidinium | 10.78 | 10.68 | 10.74 | 6.4 | 1.8 | 10.7 |
Glycopyrronium | 10.09 | 9.67 | 10.04 | 2.0 | 0.37 | 6.1 |
Tiotropium | 10.80 | 10.69 | 11.02 | 10.5 | 2.6 | 27 |
Dissociation constants determined by analysing competition kinetics curves in the presence of [N-methyl-3H]scopolamine and different concentrations of unlabelled antagonist. Data from [65].