TABLE 1

Patient demographics

Healthy subjectsNon-severe asthma patientsSevere asthma patients
Subjects555
Age years36.4±12.7242.1±16.0640.9±11
Males:females3:22:30:5
Duration of asthma yearsN/A21.2±15.3225.56±13.24
Inhaled corticosteroid dose μg BDP equivalent0480±582.711688.89±176.38
Atopy035
Receiving oral corticosteroids005
FEV1 L4.02±0.482.7±0.822.7±0.77
FEV1 % predicted104.23±7.2884.48±18.3481.42±14.82
FEV1/FVC %78.89±5.9873.98±9.6769.62±9.31
PC20 mg·mL−1>160.75±9.31Not performed

Data are presented as n or mean±sd. BDP: beclomethasone diproprionate; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; PC20: provocative concentration causing a 20% fall in FEV1.