TABLE 3

Lung tissue expression quantitative trait loci (eQTL) results for genetic variants that were serum surfactant protein D (SP-D) protein quantitative trait loci (pQTL)

ChromosomeSNPPosition (b37)Alleles#Z.LavalZ.Groningen+Z.UBC§Lung eQTL p-valueƒGene symbol##SP-D GWAS
p-value
6rs938022131150873T C−15.8−17.8−13.73.87×10−163PSORS1C38.61×10−9
10rs1226780281749610A G2.91.73.43.75×10−06SFTPD9.22×10−30
16rs1244553284404091G A−9.3−4.2−3.74.53×10−27ATP2C23.72×10−11

SNP: single-nucleotide polymorphism; GWAS: genome-wide association study; PSORS1C3: psoriasis susceptibility 1 candidate 3; SFTPD: surfactant protein D; ATP2C2: ATPase, Ca2+ transporting, type 2C, member 2. #: the SNP alleles; the first letter is the coded/effective allele; : eQTL z-score in the Laval cohort; +: z-score in the Groningen cohort; §: z-score in the University of British Colombia (UBC) cohort; ƒ: eQTL meta-analysis p-value from the UBC, Groningen and Laval studies; ##: the gene that is regulated by the eQTL.