Multiple Cox regression models assessing the effect of restrictive chronic lung allograft dysfunction (R-CLAD) and chronic lung allograft dysfunction with air trapping (AT-CLAD) on survival
| Covariate | HR (95% CI) | p-value |
| R-CLAD (ref.: non-R/AT-CLAD) | 3.57 (1.39–9.18) | 0.008 |
| Age | 0.98 (0.94–1.01) | 0.177 |
| Sex (ref.: male) | 0.43 (0.20–0.91) | 0.028 |
| Underlying disease (ref.: CF) | ||
| COPD | 1.23 (0.41–3.72) | 0.708 |
| ILD | 1.35 (0.37–4.90) | 0.647 |
| Others | 1.45 (0.37–5.67) | 0.592 |
| Severity of CLAD, FEV1/FEV1baseline % | 0.98 (0.96–1.00) | 0.093 |
| Time to CLAD years | 0.93 (0.79–1.10) | 0.414 |
| Anterolateral thoracotomy (ref.: clamshell thoracotomy) | 1.44 (0.51–4.00) | 0.490 |
| Azithromycin (ref.: no azithromycin) | 0.22 (0.07–0.71) | 0.011 |
| Cyclosporine A (ref.: tacrolimus) | 1.08 (0.38–3.13) | 0.882 |
| Year of transplantation | 1.06 (0.96–1.18) | 0.246 |
| AT-CLAD (ref.: non-R/AT-CLAD) | 2.65 (1.05–6.68) | 0.039 |
| Age | 0.98 (0.94–1.02) | 0.251 |
| Sex (ref.: male) | 1.01 (0.46–2.21) | 0.985 |
| Underlying disease (ref.: CF) | ||
| COPD | 0.64 (0.19–2.15) | 0.472 |
| ILD | 0.93 (0.27–3.21) | 0.903 |
| Others | 1.87 (0.49–7.13) | 0.362 |
| Severity of CLAD, FEV1/FEV1baseline % | 0.97 (0.94–0.99) | 0.017 |
| Time to CLAD years | 0.94 (0.78–1.13) | 0.518 |
| Anterolateral thoracotomy (ref.: clamshell thoracotomy) | 1.39 (0.54–3.55) | 0.494 |
| Azithromycin (ref.: no azithromycin) | 0.20 (0.07–0.56) | 0.002 |
| Cyclosporine A (ref.: tacrolimus) | 2.70 (0.97–7.57) | 0.058 |
| Year of transplantation | 1.18 (1.06–1.31) | 0.003 |
Data are presented as hazard ratios (HR) with 95% confidence intervals and p-values from two multiple regression models with outcome post-chronic lung allograft dysfunction (CLAD) survival. non-R/AT-CLAD: neither R- nor AT-CLAD; CF: cystic fibrosis; COPD: chronic obstructive lung disease; ILD: interstitial lung disease; FEV1: forced expiratory volume in 1 s. Bold type indicates significant values.