Variable | |
Age years | 48.5 (29.0–65.0) |
Age categories years | |
16–25 | 7 (16.7) |
26–35 | 7 (16.7) |
36–45 | 5 (11.9) |
46–55 | 9 (21.4) |
>55 | 14 (33.3) |
Sex | |
Female | 17 (40.5) |
Male | 25 (59.5) |
Ethnicity | |
White | 3 (7.1) |
Indian Subcontinent | 34 (80.9) |
Afro-Caribbean | 5 (11.9) |
Place of birth | |
UK | 3 (7.1) |
Foreign born | 39 (92.9) |
Time since entry to the UK years# | |
<1 | 7 (20.0) |
1–5 | 14 (40.0) |
6–10 | 5 (14.3) |
>10 | 9 (25.7) |
HIV status¶ | |
Negative | 34 (89.5) |
Positive | 4 (10.5) |
Monocyte:lymphocyte ratio+ | |
Pre-treatment | 0.47 (0.33–0.73) |
Post-treatment | 0.25 (0.16–0.27) |
Assessment of CNS involvement | |
Patients assessed for CNS involvement | 39 (92.9) |
Imaging of CNS§ | 28 (71.8) |
Head CT performed | 14 (50.0) |
CT abnormal | 2 (14) |
Head MRI performed | 20 (71.4) |
MRI abnormal | 13 (65) |
Lumbar puncture performed§ | 31 (79.5) |
Lumbar puncture abnormal | 5 (16.7) |
Patients with CNS involvement and test outcome | |
Total number of patients with CNS involvement§ | 15 (38.5) |
Lumbar puncture performed in those with CNS involvement | 12 (80.0) |
Lumbar puncture sensitivity % (95% CI) | 41.7 (15.2–72.3) |
Head CT performed in those with CNS involvement n | 5 |
Head CT sensitivity % (95% CI) | 40.0 (5.3–85.3) |
Head MRI performed in those with CNS involvement n | 14 |
Head MRI sensitivity % (95% CI) | 92.9 (66.1–99.8) |
Data are presented as n (%) or median (interquartile range), unless otherwise stated. CNS: central nervous system; CT: computed tomography; MRI: magnetic resonance imaging. #: data available for 35 patients; ¶: four patients did not have a HIV test; +: data available for 23 patients; §: denominator is 39 patients.