TABLE 2

Results of the two-step strategy investigating gene×environmental tobacco smoke (ETS) exposure in the 17p11 region in the Epidemiological study on the Genetics and Environment of Asthma (EGEA) discovery sample

SNP^#	Position bp^¶	Gene	Location	MAF	ETS unexposed (1)			ETS exposed (2)			FBAT homogeneity test between (1) and (2)		Umbach–Weinberg interaction test^ƒ
SNP^#	Position bp^¶	Gene	Location	MAF	n⁺	Z	p	n⁺	Z	p	χ²^§	p	n^##	Z	p
rs7225157	11680785	DNAH9	Intron	0.17	39	−2.66	0.008	52	2.09	0.037	11.22	0.0008	188	3.08	0.0016
rs1519255	12583672	MYOCD	Intron	0.13	28	3.12	0.002	35	0.91	0.362	8.31	0.0040	189	−2.07	0.0356
rs1233855	12613063	MYOCD	Intron	0.25	37	2.95	0.003	60	0.62	0.537	6.84	0.0089
rs9905908	12655081	MYOCD	Intron	0.40	45	3.03	0.002	61	−0.32	0.748	6.30	0.0120
rs2323052	13780923	COX10	Flanking 5′ UTR	0.07	29	−2.72	0.007	23	0.25	0.803	2.79	0.0947
rs6502310	13784815	COX10	Flanking 5′ UTR	0.09	34	−2.68	0.007	32	0.52	0.600	4.01	0.0452
rs4792411	13797101	COX10	Flanking 5′ UTR	0.10	28	−2.89	0.004	34	1.19	0.236	7.21	0.0072
rs9891555	14239843	HS3ST3B1	Intron	0.32	46	3.06	0.002	69	−2.11	0.035	1.09	0.2954
rs3785655	14249167	HS3ST3B1	3′ UTR	0.39	50	−2.96	0.003	64	−0.75	0.455	2.44	0.1185
rs11652573	14542140	FLJ45831	Flanking 3′ UTR	0.08	22	2.76	0.006	29	−1.07	0.285	7.66	0.0057
rs11649913	14547787	FLJ45831	Flanking 3′ UTR	0.26	40	3.16	0.002	58	1.61	0.108	1.57	0.2102
rs6502405	14834158	FLJ45831	Flanking 5′ UTR	0.39	44	2.57	0.010	66	−0.33	0.742	4.50	0.0339
rs12942402	15371906	FLJ36674	Flanking 5′ UTR	0.26	48	2.69	0.007	60	−0.75	0.451	5.48	0.0192
rs1971043	20043515	SPECC1	Flanking 5′ UTR	0.16	33	−2.97	0.003	51	−2.31	0.021	0.04	0.8358
rs7209889	20217122	SPECC1	Flanking 3′ UTR	0.15	32	−2.75	0.006	49	−1.72	0.086	−0.15
rs4473257	20823268	MGC87631	Flanking 5′ UTR	0.26	44	2.60	0.009	58	0.43	0.665	2.58	0.1085

SNP: single nucleotide polymorphism; MAF: minor allele frequency; FBAT: family-based association test; UTR: untranslated region. ^#: all SNPs showing p≤0.01 with FBAT in unexposed siblings; ^¶: dbSNP (build 37.1); ⁺: number of informative families for FBAT; ^§: Chi-squared test (1 degree of freedom); ^ƒ: applied only to SNPs reaching or being close to the significance level of interaction (p≤3×10⁻³) with the FBAT homogeneity test; ^##: number of siblings (only one per family using the Umbach–Weinberg method).