Clinical presentation of invasive pneumococcal disease in children 0–<2 years before (2005–2007) and after (2008–2014) vaccine introduction
| Incidence rate | Rate ratio (95% CI) | p-value | ||
| Before | After | |||
| Meningitis | 10.1 (16) | 4.3 (15) | 0.43 (0.21–0.86) | 0.02 |
| Septicaemia | 6.3 (10) | 2.0 (7) | 0.32 (0.12–0.84) | 0.02 |
| Pneumonia | 3.8 (6) | 2.9 (10) | 0.76 (0.28–2.09) | 0.59 |
| Rhinosinusitis | 5.0 (8) | 0.6 (2) | 0.11 (0.02–0.54) | 0.006 |
| Other# | 3.2 (5) | 0.9 (3) | 0.27 (0.07–1.14) | 0.08 |
| Total | 28.4 (45) | 10.6 (37) | 0.37 (0.24–0.58) | <0.001 |
Data are presented as n or rate per 100 000 person-years (n), unless otherwise stated. #: bacteraemia without known focus, mastoiditis, osteomyelitis, septic arthritis and cellulitis.