TABLE 9

Duration of therapy for chronic pulmonary aspergillosis (CPA)

PopulationIntentionInterventionSoRQoERef.Comment
CPA patients on  antifungal therapyControl of infection, arrest of pulmonary fibrosis, prevention of haemoptysis, improved quality of life6 months of antifungal therapyBII[15, 30, 31, 59, 83, 89, 96]Optimal duration of therapy in CPA is unknown, indefinite suppressive therapy may be appropriate in selected patients
Long-term antifungal therapy, depending on status and drug toleranceCIII[15, 30, 89, 59]
SAIA/CNPACure6 monthsBII[15, 30]Longer durations may be necessary in those with continuing immunosuppression
  • SoR: strength of recommendation; QoE: quality of evidence; SAIA: subacute invasive aspergillosis; CNPA: chronic necrotising pulmonary aspergillosis.