TABLE 6

Antibody diagnosis of chronic pulmonary aspergillosis (CPA)

Population	Intention	Intervention	SoR	QoE	Ref.	Comment
Cavitary or nodular pulmonary infiltrate in non-immunocompromised patients	Diagnosis or exclusion of CPA	Aspergillus IgG antibody	A	II	[42, 43, 44]	IgG and precipitins test standardisation incomplete
		Aspergillus precipitins	A	II	[29, 43, 45–47]	Mostly in-house tests and poorly validated; uncertain sensitivity is the major problem
		Aspergillus IgM antibody	D	III	[48]	Few data
		Aspergillus IgA antibody	D	III	[49, 50]

Intervention in context of asthma, ABPA or CF patients		Aspergillus IgE antibody	B	II	[10, 51]	Often detectable in CCPA irrespective of underling condition, with a raised total IgE

SoR: strength of recommendation; QoE: quality of evidence; ABPA: allergic bronchopulmonary aspergillosis; CF: cystic fibrosis.