Proportion of patients achieving minimally clinically important differences in measured variables
| 3 months | 6 months | |||||
| Treatment | Control | p-value | Treatment | Control | p-value | |
| Subjects n | 34 | 23 | 21 | 13 | ||
| FEV1# | 47.1 | 8.7 | 0.001 | 52.4 | 15.4 | 0.068 |
| SGRQ¶ | 58.8 | 47.8 | 0.414 | 76.2 | 46.2 | 0.159 |
| mMRC+ | 55.9 | 26.1 | 0.026 | 52.4 | 38.5 | 0.664 |
| 6MWD§ | NA | NA | NA | 52.4 | 0 | 0.0025 |
Data are presented as %, unless otherwise stated. FEV1: forced expiratory volume in 1 s; SGRQ: St George's Respiratory Questionnaire; mMRC: modified Medical Research Council dyspnoea scale; 6MWD: 6-min walking distance; NA: not available. #: MCID ≥12% and 100 mL [24] increase in post-bronchodilator FEV1 from baseline; ¶: MCID ≥4 unit decrease from baseline [26]; +: MCID ≥1 unit decrease from baseline [25]; §: MCID 26 m increase from baseline [27].