Clinical data concerning anaplastic lymphoma kinase (ALK) fluorescence in situ hybridisation (FISH)-positive and FISH-negative patients
| ALK FISH-positive patients# | ALK FISH-negative patients¶ | p-value | |
| Patients | 140 | 400 | |
| Age yrs | 62 (17–86) | 63 (30–90) | 0.003 |
| Sex | 0.007 | ||
| Males | 63 (45) | 233 (58) | |
| Females | 77 (55) | 167 (42) | |
| Tobacco habit | <0.0001 | ||
| Former and current smokers | 22 and 9 (22)§ | 129 and 71 (50)§ | |
| Nonsmokers | 64 (46) | 72 (18) | |
| Light smokers+ | 11 (8) | 24 (6) | |
| Not available | 34 (24) | 104 (26) | |
| Tobacco consumption of former and current smokers pack-years | 40 (18–60) | 40 (18–160) | 0.15 |
| Stages | 0.003 | ||
| IA | 10 (7) | 45 (11) | |
| IB | 5 (4) | 43 (11) | |
| IIA | 9 (6) | 33 (8) | |
| IIB | 4 (3) | 25 (6) | |
| IIIA | 19 (13) | 68 (17) | |
| IIIB | 5 (4) | 16 (4) | |
| IV | 53 (38) | 90 (23) | |
| Not available | 35 (25) | 80 (20) |
Data are presented as n, mean (range) or n (%), unless otherwise stated. #: ⩾15% of rearranged cells; ¶: <15% of rearranged cells; +: ⩽15 pack-years; §: total percentage of former and current smokers.