Selection criteria, number of enrolled individuals and the rate of diagnosed lung cancer of major randomised controlled trials
| Study | Selection criteria | Patients screened n (follow-up) | Lung cancer diagnosed at initial screening (total in follow-up) | |
| Age years | Tobacco smoking (delay since weaning) | |||
| DLCST | 50–70 | ≥20 pack-years (0–9 years) | 2052 (58 months) | 0.8% (3.4%) |
| DANTE | 60–74 | ≥20 pack-years (0–9 years) | 1276 (34 months) | 2.2% (4.7%) |
| (only men) | ||||
| ITALUNG | 55–69 | ≥20 pack-years (active or former) | 1406 (36 months) | 1.5% (2.8%) |
| MILD | ≥49 | ≥20 pack-years (0–9 years) | 1190# (120 months) | 0.8% (2.4%) |
| 1186¶ (53 months) | ||||
| NELSON | 50–75 | ≥15 pack-years+ (0–9 years) | 7907 (60 months) | 0.9% (2.6%) |
| NLST | 55–74 | ≥30 pack-years (0–15 years) | 26 722 (78 months) | 1.1% (2.4%) |
#: annual computed tomography; ¶: biannual computed tomography; +: NELSON inclusion criteria: number of cigarettes smoked is ≥ 15 per day for 25 years OR ≥10 cigarettes per day for 30 years AND still smoking or have quit <10 years ago.