TABLE 1

Summary of the key World Health Organization's recommendations on the minimum criteria national programmes needed to safely and effectively use new drugs

BedaquilineRequirements for countriesDelamanid
400 mg per day for 2 weeks then 200 mg three times a week for 22 weeks
Pharmacovigilance
Informed consent
QT monitoring
Country preparedness and planning
National plan new tools
Monitoring and evaluation (drug-resistance surveillance and pharmacovigilance)
Private sector engaged
Uninterrupted supply
Operational research
100 mg two times a day for 6 or 12  months added to OBR in adults
Pharmacovigilance
Informed consent
Not added to bedaquiline
  • Data taken from [4] for bedaquiline, [5] for requirements for countries, and [6] for delamanid. QT: interval measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle.