Mutation by biomarker and exon | Number of mutations in the same patient | Total n | % of gene | % of total | ||
One | Two | Three | ||||
BRAF | ||||||
Exon 15 | ||||||
V600E | 7 | 1 | 1 | 9 | ||
L597L | 1 | 1 | ||||
Total | 10 | 5% | ||||
EGFR | ||||||
Exon 18 | ||||||
G719C | 1 | 1 | 2 | |||
G719A | 1 | 1 | ||||
Unspecified | 1 | 1 | 2 | |||
Total | 5 | 3% | ||||
Exon 19 | ||||||
Deletion | 74 | 2 | 76 | |||
Unspecified | 12 | 12 | ||||
Total | 88 | 58% | ||||
Exon 20 | ||||||
c.2303_2305delinsTCT | 1 | 1 | ||||
T790M | 1 | 1 | ||||
S768I | 1 | 1 | ||||
Insertion | 4 | 4 | ||||
Duplication | 1 | 1 | ||||
Deletion | 1 | 1 | ||||
Unspecified | 1 | 1 | ||||
Total | 10 | 7% | ||||
Exon 21 | ||||||
L858R | 33 | 3 | 36 | |||
L861Q | 4 | 1 | 5 | |||
Unspecified substitution | 4 | 4 | ||||
P848L | 1 | 1 | ||||
Unspecified | 2 | 1 | 3 | |||
Total | 49 | 32% | ||||
Unspecified | 1 | 1 | ||||
Total | 1 | 1% | ||||
Total | 153 | 70% | ||||
PI3KCA | ||||||
Exon 9 | ||||||
E545K | 2 | 2 | ||||
Unspecified substitution | 1 | 1 | ||||
Unspecified | 1 | 1 | 80% | |||
Exon 20 | ||||||
Unspecified | 1 | 1 | 20% | |||
Total | 5 | 2% | ||||
HER2 | ||||||
Exon 20 | ||||||
Unspecified substitution | 1 | 1 | ||||
Unspecified insertion | 5 | 5 | ||||
Unspecified duplication | 2 | 2 | ||||
Total | 8 | 4% | ||||
KRAS | ||||||
Exon 2 | ||||||
G13D | 1 | 1 | ||||
G12V | 7 | 1 | 8 | |||
G12R | 1 | 1 | ||||
G12G | 1 | 1 | ||||
G12D | 4 | 4 | ||||
G12C | 1 | 1 | ||||
G12A | 2 | 2 | ||||
Unspecified | 1 | 1 | 2 | |||
Total | 20 | 9% | ||||
ALK | ||||||
Unspecified | 23 | 1 | 24 | |||
Total | 24 | 11% | ||||
Total | 197 | 20 | 3 | 220 | 100% |
BRAF: v-Raf murine sarcoma viral oncogene homologue B; EGFR: epidermal growth factor receptor; PIK3CA: phosphatidylinositol-3-kinase, catalytic subunit α; HER2: human epidermal growth factor receptor 2; KRAS: Kirsten rat sarcoma viral oncogene homologue; ALK: anaplastic lymphoma kinase.