Model | C-statistic (95% CI) | Change in C-statistic compared to GAP (95% CI) | NRI (95% CI) | cNRI (95% CI) | GOF |
GAP+RH | 0.776 (0.771–0.780) | 0.019 (0.011–0.027) | 7.7 (1.3–19.2) | 23.3 (7.1–60.5) | 0.998 |
GAP+UCSD SOBQ | 0.766 (0.761–0.772) | 0.009 (0.001–0.018) | 4.7 (−4.9–12.1) | 7.1 (−11.8–18.5) | 0.797 |
GAP+6MWD | 0.765 (0.753–0.776) | 0.008 (−0.005–0.021) | 11.4 (3.7–25.1) | 30.8 (8.7–56.3) | 0.025 |
GAP+FVC 24-week change | 0.762 (0.753–0.776) | 0.005 (−0.004–0.021) | 3.8 (−4.8–14.5) | 11.8 (−5.8–38.7) | 0.792 |
GAP alone | 0.757 (0.750–0.764) | 0.539 | |||
GAP+FVC decline >10% | 0.756 (0.748–0.764) | −0.001 (−0.011–0.010) | 3.5 (0.4–14.3) | 5.1 (−1.3–21.4) | 0.802 |
GAP+UCSD SOBQ 24-week change | 0.755 (0.748–0.761) | −0.002 (−0.012–0.007) | 8.3 (1.0–19.0) | 5.6 (−6.7–19.4) | 0.904 |
GAP+LTOT | 0.753 (0.745–0.761) | −0.004 (−0.014–0.007) | −0.2 (−6.3–4.0) | −1.4 (−15.3–2.5) | 0.278 |
du Bois et al.# | 0.747 (0.740–0.755) | 0.743 | |||
GAP+6MWD 24-week change | 0.744 (0.737–0.751) | −0.013 (−0.022–−0.003) | 6.5 (-2.0–17.1) | 16.0 (−10.6–36.0) | 0.041 |
GAP+DLCO 24-week change | 0.739 (0.731–0.747) | −0.018 (−0.028–−0.007) | 7.3 (1.0–17.5) | 1.5 (−16.5–9.3) | 0.885 |
GAP+6MWT desaturation | 0.732 (0.703–0.762) | −0.025 (−0.055–0.005) | 6.2 (0.6–17.1) | 17.8 (5.9–37.9) | 0.175 |
NRI: net reclassification improvement; cNRI: clinical NRI improvement; GOF: goodness-of-fit test; RH: respiratory hospitalisation; UCSD SOBQ: University of California San Diego Shortness of Breath Questionnaire; 6MWD: 6-min walking distance; FVC: forced vital capacity; LTOT: long-term oxygen therapy; DLCO: diffusing capacity of the lung for carbon monoxide; 6MWT: 6-min walk test; #: du Bois et al. model involves age, 24-week change in FVC, baseline FVC and history of RH in the preceding 24 weeks.