Rhinovirus positive | Rhinovirus negative | |||
Symptomatic | Asymptomatic | Symptomatic | Asymptomatic | |
Subjects n | 37 | 26 | 44 | 71 |
Females | 11 (31) | 14 (54) | 18 (41) | 33 (47) |
Age at first visit months | 16.8±9.4 | 27.8±4.9** | 19.5±9.4 | 28.3±3.5** |
Birth weight kg | 3.5±0.6 | 3.6±0.6 | 3.5±0.6 | 3.5±0.5 |
Prematurity | 1 (3) | 0 (0) | 0 (0) | 5 (7) |
Breast milk fed | 31 (84) | 24 (92) | 35 (80) | 66 (93) |
Parental asthma | 10 (27) | 2 (8)** | 14 (32) | 10 (14)** |
Prenatal smoke exposure | 1 (3) | 1 (4) | 4 (9) | 3(4) |
Environmental smoke exposure# | 4 (11) | 3 (12) | 7 (16) | 5 (7) |
β2-agonist use | 23 (62) | NA | 25 (57) | NA |
ICS use | 9 (24) | NA | 11 (25) | NA |
PRAM severity | 2.5±2.0 | NA | 2.4±1.7 | NA |
ACQ-based control | 14.6±7.3 | NA | 16.9±6.5 | NA |
Time to recovery weeks | 28.3±14.3 | NA | 21.1±14.9 | NA |
Positive PCR | NA | NA | 33 (75) | 12 (17)** |
Co-infection | 19 (51) | 3 (12)* | 12 (27) | 1 (1)* |
Data are presented as n (%) or mean±sd, unless otherwise stated. Breastfed infants were breastfed at least during the first month of their life. Parental asthma was defined as a parent-reported doctor diagnosis of asthma in either parent. Prenatal smoke exposure was defined as smoking by or near the mother while she was pregnant. ICS: inhaled corticosteroid; PRAM: Pediatric Respiratory Assessment Measure; ACQ: Asthma Control Questionnaire; NA: not applicable. #: missing values (n=2) were replaced by the respective group mean. *: p<0.05 for comparison with symptomatic children; **: p<0.01 for comparison with symptomatic children.