| Comparison of interest | Outcome | Reference treatment | Pooled efficacy estimate (UMEC/VI) UMEC/VI | Pooled efficacy estimate (Comparator of interest) | ITC Mean difference | 95% Confidence Interval | p-value |
|---|---|---|---|---|---|---|---|
| UMEC/VI vs IND+TIO (12 weeks) | Trough FEV1 (mL) | Tiotropium | 99.00 | 73.90 | 25.10 | -2.11, 52.30 | 0.071 |
| UMEC/VI vs QVA149 (24 weeks) | Trough FEV1 (mL) | Placebo | 167.00 | 185.59 | 6.99 | -24.05, 38.02 | 0.659 |
| Tiotropium | 92.17 | 75.38 | |||||
| SGRQ total score*(units) | Placebo | -5.51 | -3.01 | -0.50 | -4.01, 3.02 | 0.782 | |
| Tiotropium | -0.85 | -1.96 | |||||
| TDI (units) | Placebo | 1.2 | 1.09 | -0.23 | -0.80, 0.34 | 0.423 | |
| Tiotropium | 0.03 | 0.51 | |||||
| RMU* (puffs/day) | Placebo | -0.80 | -0.96 | 0.04 | -0.24, 0.33 | 0.765 | |
| Tiotropium | -0.54 | -0.55 |
*Negative score indicates favourable outcome