Table 1. The fold change of miR221 and miR222

Gene	Average ΔCt	Average ΔCt	2^-ΔCt	2^-ΔCt	%95 C.I	Fold change	p-value
	NSCLC	Control	NSCLC	Control
miR221	4.63	5.18	0.040444	0.027666	(1.39 - 1.53)	1.46	0.000095
miR222	3.16	3.87	0.111545	0.068384	(1.05 - 2.21)	1.63	0.084470
	Average ΔCt	Average ΔCt	2^-ΔCt	2^-ΔCt	%95 C.I	Fold change	p-value
	T3+T4	T1+T2	T3+T4	T1+T2
miR221	4.01	5.40	0.062144	0.023678	(2.23- 3.01)	2.62	0.000165
miR222	2.23	4.31	0.213465	0.050513	(2.12- 6.34)	4.23	0.007449
	Average ΔCt	Average ΔCt	2^-ΔCt	2^-ΔCt	%95 C.I	Fold change	p-value
	Metastases(+)	Metastases(-)	Metastases(+)	Metastases(-)
miR221	3.62	4.84	0.081488	0.034958	(1.66- 3.00)	2.33	0.014585
miR222	5.36	2.49	0.024360	0.177885	(0.06- 0.22)	0.14	0.006675
	Average ΔCt	Average ΔCt	2^-ΔCt	2^-ΔCt	%95 C.I	Fold change	p-value
	Advanced stage	Early stage	Advanced stage	Early stage
miR221	7.06	7.59	0.007485	0.005190	(1.36- 1.52)	1.44	0.000387
miR222	1.95	2.56	0.258048	0.169796	(1.43- 1.61)	1.52	0.000302