PK data
| INH | RIF | PZA | EMB | ||
| Cmax (mg/L) | iv | 6.6 ±2.9 | 12.6 ±2.9 | - | 5.5 ±1.8 |
| fasting | 4.7 ±1.4a | 11.5 ±2.8 | 45.9 ±9.3 | 3.1 ±1.4a | |
| fed | 2.7±1.4bc | 8.7±2.5bc | 40.7±7.8c | 2.5±0.8bc | |
| Tmax (h) | iv | 0.8±0.3 | 1.8±0.7 | - | 1.4±0.6 |
| fasting | 1.2 ±0.6a | 2.1 ±0.5a | 1.5 ±0.6 | 2.9 ±0.9a | |
| fed | 2.9 ±1.6bc | 4.1 ±2bc | 3.3 ±1.7c | 3.6 ±1.4bc | |
| AUC0-24 (mg.h/L) | iv | 17.4 ±8.4 | 87.1 ±29.5 | - | 15.1±5.4 |
| fasting | 19.4 ±12.3 | 77.6 ±29.7a | 518.1 ±137.6 | 17.6 ±5.6 | |
| fed | 15.3 ±10.3bc | 61.4 ±23bc | 491.4 ±121.5 | 17.6 ±6.9 | |
| Bioavailability (%) | Fasting/iv | 106 | 87 | - | 98 |
| Fed/iv | 84c | 70c | - | 95 | |
| Fed/fasting | - | - | 95 | - |
a p<0.05 (fasting vs iv) b p<0.05 (fed vs iv) c p<0.05 (fed vs fasting)