Drug | Mode of action |
Sulforaphane | Nfr2 activation |
Resveratol | Antioxidant, SIRT activation, AMPK activation, PI3K activation |
Metformin | AMPK activation, SIRT1 activation, mTOR inhibition, anti-oxidant |
Melatonin | Anti-oxidant, anti-inflammatory |
Rapamycin | mTOR inhibition |
Low-dose theophylline | PI3Kδ activation |
Nrf2: nuclear factor erythroid 2-related factor2; AMPK: AMP-activated protein kinase; PI3K: phosphatidylinositide 3-kinases; mTOR: mammalian target of rapamycin.