Table 2– Risk of bias and applicability concerns summary: review authors’ judgements about each domain for each study included

First author [ref.]	Risk of bias				Applicability bias
	Patient selection	Index test	Reference standard	Flow and timing	Patient selection	Index test	Reference standard
Reddy [30]	+	+	+	+	+	+	+
Vargas [31]	–	+/–	+/–	–	+	+	+
Ha [32]	+	+/–	+/–	–	+	+	+
Caws [35]	+	+	–	+	+	+	+
Ha [36]	+	+	–	+	+	+	+
Makamure [37]	+/–	+	+/–	+	+	+	+
Moore [38]	+	+	+	+	+	+	+
Oberhelman [39]	–	+/–	–	+	+	+	+
Shah [40]	+	+/–	+/–	+	+	+	+
Solomon [41]	+/–	+	+	+/–	+	+	+

+: authors’ judgement positive, low risk of bias or applicability concern; +/–: authors’ judgement neutral, unclear risk of bias or applicability concern; –: authors’ judgement negative, high risk of bias or applicability concern.