Table 2– Association of imputed classical human leukocyte antigen (HLA) class II alleles, rs9273349, and adult-onset asthma in all ESE and B58C subjects, and according to ever having been exposed to occupational high molecular weight (HMW) allergens

HLA-II allele	AF^#	All subjects^¶	HMW allergen exposed⁺	HMW allergen unexposed^§	p-value
					Joint test	Interaction
**DRB101:01***	9.4	0.83 (0.68–1.01)	0.83 (0.57–1.21)	0.83 (0.66–1.04)	0.18	0.99
**DRB103:01***	12.6	1.09 (0.92–1.29)	1.05 (0.79–1.40)	1.11 (0.91–1.36)	0.52	0.75
**DRB104:01***	9.9	1.10 (0.91–1.33)	1.11 (0.80–1.55)	1.10 (0.87–1.38)	0.56	0.94
**DRB107:01***	13.3	1.04 (0.89–1.23)	1.12 (0.84–1.49)	1.01 (0.83–1.23)	0.73	0.58
**DRB115:01***	12.5	0.88 (0.74–1.04)	0.88 (0.65–1.20)	0.88 (0.72–1.07)	0.35	0.98
**DQA101:01***	15.1	0.91 (0.78–1.06)	0.97 (0.72–1.31)	0.88 (0.73–1.06)	0.44	0.59
**DQA101:02***	18.4	0.91 (0.79–1.05)	0.95 (0.73–1.23)	0.90 (0.76–1.06)	0.45	0.73
**DQA101:03***	6.8	0.81 (0.65–1.01)	0.75 (0.49–1.16)	0.83 (0.64–1.07)	0.17	0.71
**DQA102:01***	13.4	1.04 (0.88–1.22)	1.11 (0.83–1.49)	1.01 (0.83–1.23)	0.74	0.57
**DQA103:01***	18.6	1.09 (0.95–1.26)	1.06 (0.82–1.36)	1.11 (0.93–1.32)	0.41	0.78
**DQA105:01***	25.1	1.12 (0.99–1.27)	1.04 (0.83–1.30)	1.16 (1.00–1.34)	0.12	0.42
**DQB102:01***	17.8	1.06 (0.92–1.22)	1.09 (0.85–1.41)	1.05 (0.89–1.24)	0.63	0.78
**DQB103:01***	19.1	1.12 (0.98–1.28)	1.07 (0.84–1.38)	1.14 (0.97–1.33)	0.23	0.72
**DQB103:02***	10.6	1.08 (0.91–1.29)	1.18 (0.86–1.61)	1.04 (0.85–1.29)	0.53	0.54
**DQB105:01***	12.3	0.89 (0.75–1.06)	0.98 (0.71–1.35)	0.86 (0.70–1.06)	0.38	0.51
**DQB106:02***	12.0	0.90 (0.76–1.06)	0.92 (0.67–1.25)	0.89 (0.73–1.09)	0.48	0.87
**DQB106:03***	6.3	0.80 (0.64–1.01)	0.79 (0.51–1.23)	0.81 (0.62–1.06)	0.20	0.93
**DPA101:03***	18.8	0.94 (0.80–1.10)	0.92 (0.70–1.21)	0.95 (0.78–1.15)	0.75	0.86
**DPA102:01***	14.9	0.96 (0.81–1.14)	1.06 (0.79–1.43)	0.92 (0.75–1.12)	0.66	0.42
**DPB102:01***	13.4	1.19 (1.02–1.39)	1.02 (0.76–1.38)	1.25 (1.05–1.50)	0.04	0.25
**DPB103:01***	10.3	0.80 (0.65–0.97)	1.08 (0.77–1.49)	0.67 (0.53–0.86)	0.007	0.03
**DPB104:01***	42.4	1.03 (0.92–1.15)	1.02 (0.83–1.25)	1.03 (0.90–1.18)	0.87	0.94
**DPB104:02***	11.1	1.01 (0.85–1.21)	0.94 (0.68–1.29)	1.05 (0.84–1.30)	0.84	0.58
rs9273349 T	40.8	0.82 (0.72–0.93)	0.81 (0.64–1.03)	0.82 (0.71–0.95)	0.009	0.95

Data are presented as OR (95% CI) unless otherwise stated. AF: allele frequency. ^#: weighted average in ESE and B58C; ^¶: n = 5079; ⁺: n = 1683; ^§: n = 3396. Bold face indicates p<0.05.