Tolerability and outcome of PINPOINT therapy

Table 1Group AGroup B
Mean Age6461
Sex ratio (M:F)14:166:18
Mean baseline SpO2 (%)9593
Mean FEV1 (L)1.441.21
Mean FVC (L)1.561.32
Home O265
Home BiPAP12
Mean Pirfenidone dose (mg/kg/day)1718
Mean absolute Pirfenidone dose (mg/day)1009950
Adverse reactions65
Stop Pirfenidone64
Acute Exacerbation56
Death46
Median duration from start of Symptoms to PINPOINT (months)3 (1-60)13 (3 -61)
Median duration from start of PINPOINT to last follow up/ stop Pirfenidone/ Death9 (1-21)10 (1-22)