| KC study (mean/%CV) | CM study (mean/%CV) | |||
| Riociguat (n=16) | Riociguat + KC (n=16) | Riociguat (n=14) | Riociguat + CM (n=14) | |
| AUC (μg⋅h/L) | 81.9/78.6 | 204.9/44.9 | 171.1/97.0 | 240.0/88.9 |
| Cmax (μg/L) | 9.4/29.9 | 13.7/19.3 | 20.8/37.7 | 21.6/33.9 |
| t1/2 (h) | 7.3/78.5 | 9.2/57.1 | 6.4/77.1 | 7.9/54.6 |
AUC, area under plasma conc.–time curve; Cmax, max. plasma riociguat conc.; CV, coefficient of variation; t1/2, elimination half-life.