Table: Mean treatment difference in symptom scores
| Least squares mean treatment difference (SE) | ||||||
| SHINE (26wks) | ENLIGHTEN (52wks) | ILLUMINATE (26wks) | ||||
| QVA149–placebo | QVA149–indacaterol | QVA149–glycopyrronium | QVA149–open-label tiotropium | QVA149–placebo | QVA149–salmeterol/fluticasone | |
| Nights with no nighttime awakenings, % | 10.01 (2.368)*** | 1.20 (1.892) | 5.05 (1.910)** | 3.68 (1.891) | 6.32 (3.610) | –1.38 (2.395) |
| Days with no daytime symptoms, % | 3.05 (1.485)* | –1.68 (1.180) | 1.09 (1.191) | 1.95 (1.180) | 5.30 (2.100)* | 2.50 (1.262)* |
| Days able to perform daily activities, % | 11.48 (2.529)*** | 5.04 (2.014)* | 5.87 (2.034)** | 8.45 (2.014)*** | 8.13 (3.676)* | –1.24 (2.540) |
| Daily total symptom score | –0.67 (0.145)*** | –0.13 (0.116) | –0.26 (0.117)* | –0.24 (0.116)* | –0.57 (0.224)* | –0.05 (0.125) |
***p<0.001, **p<0.01, *p<0.05