Mean Rate of Decline mL/year, median (Q1,Q3)
	First exacerbation
	Before	After	P-value
Pre-BD FEV1	-27.5 (-101.1, 49.5)	-48.7 (-134.1, 22.2)	0.0006
Post-BD FEV1	-27.8 (-97.0, 41.7)	-59.0 (-132.7, 15.7)	0.0002
Pre-BD FVC	-54.9 (-202.5, 99.8)	-61.1 (-230.3, 94.2)	0.0403
Post-BD FVC	-58.6 (-187.3, 92.4)	-65.5 (-216.6, 61.2)	0.0775