Table1
| Group 1 | Group 2 | Group 3 | |
| Patients numbers | 10 | 16 | 15 |
| Age (years) | 54,7±13,8 | 65,5±9 | 67,8±6,3 |
| Tobacco (pack/years) | 27,2±15,3 | 55±19 | 67,9±38 |
| BMI (kg/m2) | 20±1 | 18,7±1,7 | 17,5±1,5 |
| FFMI (kg/m2) | 16,9±1,3 | 15,9±1,1 | 15,5±0,9 |
| MRC | 2,6±0,5 | 3,5±0,8 | 4±1 |
| %FEV1 | 36,6±13,8 | 29,3±9,4 | 25,9±9,8 |
| ISWT (meters) | 282±108 | 174±118 | 123±108 |
| SGRQ Symptom | 67,1±9,1 | 67,3±13 | 73,3±14 |
| SGRQActivity | 71,9±22,2 | 77,2±19,7 | 82±20 |
| SGRQimpact | 58,5±17,6 | 62±21 | 57,7±23,3 |
| SGRQTotal | 64,1±16 | 67,6±15,5 | 67,8±19 |