| Parameter | Group 1 (bosentan 125mg) | Group 1 (bosentan 125mg) | Group 1 (bosentan 125mg) | Group 2 (bosentan 250mg) | Group 2 (bosentan 250mg) | Group 2 (bosentan 250mg) | Normal control |
| Baseline | wk3 | wk12 | Baseline | wk3 | wk12 | ||
| IL-1β (pg/ml) | 1.8 (1.5-2.8) | 0.6 (0.3-0.9)* | 0.8 (0.7-1.1) | 1.5 (0.5-1.9) | 0.5 (0.1-1.2)* | 0.7 (0.4-1.1) | 1.5 (1.1-2.2) |
| IL-8 (pg/ml) | 10.6 (5.1-16.2) | 16.2 (6.8-18.7) | 8.1 (7.6-11.0)* | 24.3 (11.0-28.8)# | 20.2 (13.7-17.5) | 15.8 (8.2-25.4)#* | 8.2 (6.7-12.0)ˆ |
| TNFα (pg/ml) | 19.4±6.5 | 19.6±3.9 | 20.1±2.9 | 22.3±4.2 | 21.7±5.4 | 23.7±3.4 | 9.34±3.51ˆ |
^ p<0,05 IPAH pts vs control, * p<0,05 vs baseline, # p<0,05 group 1 vs group 2