Comparison at baseline and after treatment (FP, n=23 and placebo, n=11)

MarkersBefore (FP)After (FP)Before (Placebo)After (Placebo)
% Rbm fragmentation19.1 (0.2-42.8)*2.6 (0-88.6)†24.0 (6.6-100)26.9 (2.5-48.5)
S100A4 positive cells in BE per mm of Rbm25.8 (2.4-55.3)*12.3 (0.6-24.9)†19.8 (2.9-31.6)17.4 (10.3-35.5)
S100A4 positive cells in Rbm per mm of Rbm44.4 (15.3-92.6)*20.8 (2.6-60.7)†23.1 (14-82.9)29.3 (3.6-48.1)
MMP-9 positive cells in Rbm clefts per mm of Rbm0.6 (0-22.4)*0 (0-10.6)†1.1 (0-4.1)1.3 (0-2.7)
EGFR % epithelium34 (14.6-59.5)*5.8 (2.6-43.8)†14.4 (3.6-38.2)10.3 (1.3-39.1)
  • Data expressed as medians and ranges. * No significant difference at baseline. † Significant difference after treatment with FP (p<0.03).