| Non-PH | Pre-capillary PH | p-value | |
| Patients n | 19 | 10 | |
| Peak WR W | 49 (38–55) | 45 (30–64) | 0.70 |
| Metabolic responses | |||
| Peak V′O2 % predicted | 80±13 | 68±20 | 0.06 |
| Peak V′O2 mL·kg−1·min−1 | 15.0±2.5 | 12.8±1.6 | 0.02 |
| V′O2 at AT¶ % V′O2max predicted | 50±8 | 41±11 | 0.04 |
| ΔV′O2/ΔWR mL·min−1·W−1 | 8.8±1.6 | 9.9±2.9 | 0.24 |
| Cardiovascular responses | |||
| Peak heart rate beats·min−1 | 124±22 | 121±14 | 0.72 |
| Peak heart rate % predicted | 77±15 | 76±5 | 0.75 |
| Δheart rate/ΔV′O2 beats·L−1 | 69±27 | 62±24 | 0.27 |
| Peak V′O2/heart rate % predicted | 97 (85–117) | 99 (62–110) | 0.51 |
| Peak SBP mmHg | 170 (160–170) | 155 (150–163) | 0.05 |
| Ventilatory responses | |||
| V′E/MVV | 0.61 (0.51–0.92) | 0.66 (0.60–0.86) | 0.65 |
| ΔV′E/ΔV′CO2 | 40±5 | 42±6 | 0.78 |
| V′E/V′CO2 at AT¶ | 37±7 | 38±7 | 0.67 |
| Peak PETCO2 mmHg | 35±4 | 36±5 | 0.61 |
| PETCO2 at AT¶ mmHg | 37±4 | 38±5 | 0.79 |
| Peak SpO2 % | 93 (86–95) | 87 (84–90) | 0.06 |
| Subjective responses | |||
| Peak dyspnoea Borg score | 5±2 | 6±2 | 0.51 |
| Peak leg effort Borg score | 6±2 | 5±3 | 0.31 |
Data are presented as median (interquartile range) or mean±sd, unless otherwise stated. PH: pulmonary hypertension; WR: work rate; V′O2: oxygen uptake; AT: anaerobic threshold; Δ: change in; SBP; systolic blood pressure; V′E: minute ventilation; MVV: maximal voluntary ventilation; V′CO2: carbon dioxide production; PETCO2: end-tidal carbon dioxide tension; SpO2: arterial oxygen saturation measured by pulse oximetry. #: n=29; ¶: we were not able to determine the AT in eight patients (three from the pre-capillary PH group).