Table 5– Most significant genome-wide association results for the overlap of chronic obstructive pulmonary disease and asthma among African–Americans

Chromosome	SNP	Gene/nearest gene	Minor allele	MAF	OR (95% CI)	p-value
7	rs2686829	PKD1L1	T	0.14	2.41 (2.07–2.75)	4.03×10⁻⁷
13	rs9577395	ATP11A	G	0.08	0.35 (-0.09–0.78)	1.90×10⁻⁶
10	rs3864801	REEP3	C	0.29	2.23 (1.90–2.56)	1.94×10⁻⁶
8	rs12681559	NRG1	G	0.07	0.36 (-0.06–0.78)	2.25×10⁻⁶
4	rs28895885	AGA	T	0.05	0.28 (-0.26–0.81)	2.72×10⁻⁶
10	rs6479918	REEP3	G	0.32	2.06 (1.75–2.36)	3.63×10⁻⁶
1	rs115905118	KCNK1	C	0.06	0.33 (-0.14–0.80)	3.79×10⁻⁶
13	rs12585036	ATP11A	T	0.09	0.40 (0.0–0.79)	3.84×10⁻⁶
4	rs10213448	AGA	T	0.05	0.28 (-0.25–0.82)	3.90×10⁻⁶
1	rs16859141	KCNK1	A	0.06	0.33 (-0.14–0.80)	4.51×10⁻⁶

Genes either contain the variant or are located within 500 kb of the variant. SNP: single nucleotide polymorphism; MAF: minor allele frequency.