| Subjects | Yes for current wheeze | Yes for ever wheeze | Yes for physician-diagnosed asthma ever | |||||||||||||
| Subjects | Unadjusted | Adjusted | Subjects | Unadjusted | Adjusted | Subjects | Unadjusted | Adjusted | ||||||||
| OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | |||||
| GENESIS# | 1668 | 449 (27) | 611 (36.6) | 164 (9.8) | ||||||||||||
| Growth velocity | ||||||||||||||||
| Normal | 573 (35) | Reference | Reference | Reference | Reference | Reference | Reference | |||||||||
| Retarded | 324 (19) | 0.92 (0.67–1.26) | 0.624 | 0.95 (0.69–1.32) | 0.782 | 1.26 (0.94–1.67) | 0.112 | 1.27 (0.95–1.71) | 0.104 | 0.93 (0.56–1.55) | 0.797 | 0.95 (0.56–1.60) | 0.852 | |||
| Rapid | 771 (46) | 1.12 (0.87–1.42) | 0.366 | 1.15 (0.89–1.45) | 0.266 | 1.39 (1.11–1.74) | 0.005 | 1.40 (1.11–1.78) | 0.004 | 1.51 (1.04–2.19) | 0.027 | 1.52 (1.02–2.25) | 0.036 | |||
| Healthy Growth Study¶ | 1867 | 65 (3.5) | 230 (12.3) | 247 (13.2) | ||||||||||||
| Growth velocity | ||||||||||||||||
| Normal | 1050 (56) | Reference | Reference | Reference | Reference | Reference | Reference | |||||||||
| Retarded | 197 (11) | 1.95 (0.93–4.08) | 0.076 | 1.78 (0.83–3.8) | 0.138 | 1.11 (0.70–1.76) | 0.640 | 1.13 (0.71–1.79) | 0.600 | 1.38 (0.91–2.10) | 0.123 | 1.31 (0.85–2.03) | 0.220 | |||
| Rapid | 620 (33) | 1.66 (0.97–2.84) | 0.064 | 1.54 (0.87–2.74) | 0.137 | 1.20 (0.89–1.62) | 0.224 | 1.11 (0.80–1.53) | 0.523 | 1.03 (0.77–1.39) | 0.814 | 1.10 (0.79–1.53) | 0.565 | |||
Data are presented as n or n (%) unless otherwise stated. Adjusted for maternal age at birth, maternal prenatal smoking, gestational age, birth weight, sex, parity, breastfeeding (any time of exclusive breastfeeding versus formula only versus any time of mixed feeding), parental educational level, passive smoking at home, body mass index, waist circumference, sum of skinfold thickness (biceps, triceps, subscapular and suprailiac), for both studies. The GENESIS participants were also adjusted for parental-reported atopic dermatitis. Bold represents statistically significant correlations. GENESIS: Growth, Exercise and Nutrition Epidemiological Study In preSchoolers. #: children aged 2–5 years; ¶: children aged 9–13 years.